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These changes affect saliva production, consequently impacting nutrition and oral health

Nuclei isolation from sorted cells was performed for Single-cell Multiome (10x Genomics)

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Due to the conformational differences between the P72 and R72 missense mutants, we speculated that their propensity for rescue by p53 targeting drugs, such as APR-246, may differ in that mutants with the P72 SNP would exhibit increased sensitivity